The clinical problem.
Every year, more than 1.7 million people worldwide suffer from meningitis and oh, point one, seven
million people die due to bacterial meningitis. Hence the need for a rapid and sensitve detection
method arises in neurological infections
24 HOURS : EVERY MINUTES COUNTS
If Hardy and an adequate treatment is not initated, it can result in death within 24 hours.
Conventional algorithm vs neurology multiplex diagnosis
Patient with suspected infection
Conventional approach
Symptomatic diagnosis
Infinite diagnosis.
Checks only for signs and symptoms of neurological infections.
This includes fever, vomiting, headache confusion, scissors, sleepiness
Culture.
Significant only in bacterial meningitis.
Takes 72 hours for final result.
Isolation of fastidious organism has low sensitivity. 25 to 30%.
Transportation of sample decides the viability of bacteria.
Serology.
Takes at least five to seven days for a positive result.
Low sensitivity, 20%
No relevance in active patient management
ID-Neurology Multiplex PCR.
Detects bacteria viruses and fungi.
Faster diagnosis within 5 hours
Helps in active patient treatment decisions.
High sensitivity and specificity
Multiplex PCR: Solution for unmet needs.
ID Neurology Multiplex panel is a one-step real time multiplex PCR assay that detects and
identifies more than 35 neurological pathogens simultaneously.
Rapid and accurate identification of pathogens results in early diagnosis.
Viral meningitis is often assumed to be a largely benign self-limiting disease; however, it is true
only for pathogens like Enterovirus.
High sensitivity in patients on prior antibiotic therapy.
Multiplex PCR is much more sensitive than the culture method in those patients who have
received antibiotics before the collection of the CSF sample.
High sensitivity of Multiplex PCR in suspected TBM cases.
Timely and accurate diagnosis provides a favorable prognosis in patients with TBM