Infectious serology

Infectious serology testing is a diagnostic method used to detect the presence of antibodies or antigens in a person's blood, which can indicate a current or past infection. These tests help identify and monitor infectious diseases by measuring the immune response to pathogens such as viruses, bacteria, fungi, and parasites.

Key points about infectious serology testing:

  1. Types of Serologic Tests:
    - Antibody Tests: These detect specific antibodies (IgM, IgG, IgA) produced by the immune system in response to an infection. IgM antibodies usually indicate a recent or acute infection, while IgG antibodies suggest past exposure or chronic infection.

    Antigen Tests: These identify the presence of specific antigens, which are parts of the pathogen itself, indicating an active infection.

  2. Common Uses:
    Diagnosis: Helps confirm the presence of infectious diseases such as HIV, hepatitis, COVID-19, syphilis, and many others.

    Screening: Used for blood donor screening to prevent the transmission of infectious diseases through blood transfusions.

    Epidemiological Studies: Assists in understanding the spread and prevalence of infectious diseases within populations.

    Vaccine Efficacy: Evaluates the immune response to vaccinations.

  3. Methods:
    Enzyme-Linked Immunosorbent Assay (ELISA): Commonly used to detect antibodies or antigens with high sensitivity and specificity.

    Western Blot: Used to confirm positive results from initial screening tests, especially in the context of HIV testing.

    Rapid Tests: Provide quick results, often used in point-of-care settings.

    Immunofluorescence Assays (IFA): Detect antibodies using fluorescence microscopy.

  4. Interpretation: - Positive results indicate the presence of antibodies or antigens, suggesting exposure to the pathogen.

    - Negative results imply no detectable antibodies or antigens, though it might be too early in the infection for detection, or the individual might not have been exposed.

Infectious serology testing plays a vital role in diagnosing and managing infectious diseases, contributing to public health surveillance and individual patient care.